The spring 2019 Research Grant Program application period is now closed.

To receive future notifications of ALGSA Research Grant open application periods, please email alagille@alagille.org.

ALGSAndScience – 2019 Research Grant Program

Thank you for your interest in applying for a research grant from the Alagille Syndrome Alliance (ALGSA: www.alagille.org). These guidelines provide a brief introduction to the goals and policies of the ALGSA, and list the specific information required when submitting a proposal.

Research Grant Policies and Procedures

The purpose of the ALGSA is to advocate for better treatments and a cure for those with Alagille Syndrome (ALGS). The ALGSA is also dedicated to increasing public awareness of ALGS, supporting research efforts on behalf of the ALGS community, and educating families, friends and healthcare providers about ALGS.

ALGS is a rare genetic condition that affecting about one in 35,000 individuals. Both its symptoms and severity are highly variable and substantial research is needed to understand its complexities. For this reason, the ALGSA awards grants to applicants who seek to conduct basic, pre-clinical, translational, and clinical research projects that investigate all aspects of ALGS. The ALGSA is particularly interested in funding research projects that have the potential to accomplish one or more of the following:

  • Identify novel therapies that may significantly improve the quality of life of individuals with ALGS;
  • Address an important or novel research question related to ALGS;
  • Investigate an aspect of ALGS that is less well researched or is a promising new area for research;
  • Promote and encourage ALGS research in young investigators;
  • Complement the goals and objectives of the NIDDK (National Institute of Diabetes and Digestive and Kidney Diseases) funded pediatric liver disease consortium ChiLDReN (Childhood Liver Disease Research and Education Network; www.childrennetwork.org) and make use of clinical data available to the network;
  • Produce preliminary data that would facilitate broader or more substantial funding from agencies, foundations, or corporations in the future;
  • Discover a cure for ALGS.

Proposed project must have specific relevance to ALGS, and show promise for contributing to the scientific advancement in the field of study. Proposals that have little or no relevance to ALGS will not be considered for funding. The ALGSA strongly encourages interdisciplinary collaboration and the sharing of resources as a means of accelerating progress in ALGS research. ALGSA endorses the principles of the Association of American Medical Colleges (AAMC) report, “The Maintenance of High Ethical Standards in the Conduct of Research.” ALGSA does not fund research that involves the use of human fetal tissue.

Applicant Eligibility

To be eligible to apply for research grant funding from the ALGSA, individuals or teams of Applicants must demonstrate the following:

    1. Applicant(s) must have a Ph.D., M.D., or equivalent degree;
    2. Applicant(s) must currently hold a full-time position at any level (post-doctoral, research scientist, assistant/associate/full professor, etc.) at an academic institution or in the pharmaceutical/biotechnology industry;
    3. Applicant(s) will be considered from both the United States and internationally.

Funding Guidelines and Limitations

Funding is limited to $5,000 US for one (1) year. The following will not be funded by the ALGSA:

  • Overhead or indirect costs;
  • Collaborator salaries;
  • Salaries or stipends for students;
  • General institutional expenses;
  • General fundraising campaign expenses such as dinners and mass mailings;
  • Religious, political, or other research that does not fall within the ALGSA’s areas of interest, as described in Section I of these Research Grant Proposal Guidelines;
  • Miscellaneous expenses unrelated to the research project including but not limited to journal subscriptions, advertisements, tuition fees, professional society dues, meals, receptions, or parking fees

Research grant funds awarded by the ALGSA must be used for the specific purpose for which they were originally intended in the grant proposal. Any funds not used in the manner specified in the grant award must be returned to the ALGSA. Applicant(s) may apply for an extension of time to use remaining funds at the end of the grant period.

Grant recipients shall provided a one to two (1 to 2) page mid-year Research Grant Progress Report summarizing results obtained with funds provided by the ALGSA. A template for the Progress Report is included as the last two pages of these Guidelines. The Report must indicate plans for publication of research findings in scientific or medical journals. The ALGSA requests that all publications or presentations resulting from research funded by the ALGSA include an acknowledgement of this support and, where possible, our contact information.

Full Proposal Instructions: Applications are no longer being accepted for the spring 2019 ALGSA Research Grant cycle

Please direct questions to alagille@alagille.org and use “Research Grant” in the subject line.


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